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GVHD Prevention: An Ounce Is Better Than a Pound

Year: 2012
Type: review
Abstract: The pathophysiology of acute graft-versus-host disease (aGVHD) is known to involve donor T cells responding to host histoincompatible allo-antigens presented by the host antigen presenting cells (APCs) and the subsequent induction of pro-inflammatory cytokines and cellular effectors that cause target organ damage. In a more general sense, GVHD can be considered as an immune response against foreign antigens that has gone awry. Similar to all immune responses, GVHD, can be understood as a process that consists of (A) triggers, (B) sensors, (C) mediators, and (D) effectors of GVHD.
DOI: 10.1016/j.bbmt.2011.10.034
Institutions: University of Michigan, U-M Rogel Cancer Center, Inserm, Assistance Publique – Hôpitaux de Paris, Hôpital Saint-Louis, Université Paris Diderot, Harvard University, Dana-Farber Cancer Institute, Masonic Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2146003774
FWCI: 0.305
Cites: 122
Cited by: 12
Related to: 10