Work

Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration

Year: 2012

Type: article

Abstract: Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss.

Source: Advanced Materials

DOI: 10.1002/adma.201200634

Authors: Justin Tan, Yajun Wang, Xiaopei Yip, Fergal Glynn, Robert K. Shepherd, Frank Caruso

Institutions: Bionics Institute, The University of Melbourne

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: State Government of Victoria, National Institutes of Health, Medical Research Council, National Health and Medical Research Council