Work

Targeting toll-like receptor signaling as a novel approach to prevent ocular infectious diseases.

Year: 2013

Type: article

Abstract: Toll-like receptors (TLRs) play a key role in the innate immune response to invading pathogens. Thus, their discovery has opened up a wide range of therapeutic possibilities for various infectious and inflammatory diseases. In the last several years, extensive research efforts have provided a considerable wealth of information on the expression and function of TLRs in the eye, with significant implications for better understanding of pathogenesis of infectious eye diseases affecting the cornea, uvea, and the retina. In this review, by using bacterial keratitis and endophthalmitis as examples, we discuss the possibilities of targeting TLR signaling for the prevention or treatment of ocular infectious diseases.

Source: PubMed Central

Authors: Rajeev K Pandey, Fu-Shin Yu, Ashok Kumar

Institutions: Kresge Eye Institute, Wayne State University

Language: English

Topic: Ocular Infections and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Eye Institute

Award: Interleukin-1 cytokines in regulating corneal innate immunity against microbial infection