Altered antisense-to-sense transcript ratios in breast cancer
Year: 2010
Type: article
Study design: Observational Study
Abstract: Transcriptome profiling studies suggest that a large fraction of the genome is transcribed and many transcripts function independent of their protein coding potential. The relevance of noncoding RNAs (ncRNAs) in normal physiological processes and in tumorigenesis is increasingly recognized. Here, we describe consistent and significant differences in the distribution of sense and antisense transcripts between normal and neoplastic breast tissues. Many of the differentially expressed antisense transcripts likely represent long ncRNAs. A subset of genes that mainly generate antisense transcripts in normal but not cancer cells is involved in essential metabolic processes. These findings suggest fundamental differences in global RNA regulation between normal and cancer cells that might play a role in tumorigenesis.
Institutions: Brigham and Women's Hospital, Harvard University, Dana-Farber Cancer Institute, The University of Texas MD Anderson Cancer Center, Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital, Russian Academy of Sciences, Vavilov Institute of General Genetics, Harvard Stem Cell Institute
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
Funders: U.S. Department of Defense, Avon Foundation for Women, Susan G. Komen for the Cure, Breast Cancer Research Foundation, Brigham and Women's Hospital, Harvard University, Terri Brodeur Breast Cancer Foundation, Belfer Center for Science and International Affairs, Harvard University, National Cancer Institute
Awards: G1295147849, G4119534169, G4258809411
OpenAlex ID: W2146168810