Work

Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells

Year: 2005

Type: preprint

Abstract: Radial glia function during CNS development both as neural progenitors and as a scaffolding supporting neuronal migration. To elucidate pathways involved in these functions, we mapped in vivo the promoter for Blbp, a radial glial gene. We show here that a binding site for the Notch effector CBF1 is essential for all Blbp transcription in radial glia, and that BLBP expression is significantly reduced in the forebrains of mice lacking the Notch1 and Notch3 receptors. These results identify Blbp as the first predominantly CNS-specific Notch target gene and suggest that it mediates some aspects of Notch signaling in radial glia.

Source: Genes & Development

DOI: 10.1101/gad.1302105

Authors: Todd E. Anthony, Heather A. Mason, Thomas Gridley, Gord Fishell, Nathaniel Heintz

Institutions: Howard Hughes Medical Institute, Rockefeller University, Jackson Laboratory, New York University

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: Howard Hughes Medical Institute, March of Dimes Foundation, Children's Brain Tumor Foundation, National Institutes of Health

OpenAlex ID: W2146180544

Cites: 39

Cited by: 239

Related to: 9