The Renal Clearances of Substituted Hippuric Acid Derivatives and Other Aromatic Acids in Dog and Man 1
Year: 1945
Type: article
Abstract: The efficiency with which diodrast (3, 5-di-iodo-4-pyridone-1-acetic acid) and hippuran (o-iodohippuric acid) are excreted by the renal tu-bules (1, 2) raises the question to what extent the organically-bound iodine in these molecules is responsible for the phenomenon of tubular excre-tion. Since suitable quantitative methods for the determination of unsubstituted compounds wvere not available, substituted derivatives of hippuric acid which could be determined by appropriate coupling reactions were prepared 2 and studied under conditions permitting the exact comparison of renal clearances with those of diodrast atnd hippuran. Methods of comparing clearances. When two substances, both of which are excreted by the tubules, are presented to the tubular excretory mechanism simultaneously, one substance may de-press the tubular excretion of the other (2, 3).3 Consequently, in the absence of information to
DOI: 10.1172/jci101618
Authors: Homer W. Smith, Norma Finkelstein, Lucy Aliminosa, Betty Crawford, Martha Graber
Institution: New York University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2146351587