Work

Evidence That Purifying Selection Acts on Promoter Sequences

Year: 2011

Type: article

Abstract: We tested whether functionally important sites in bacterial, yeast, and animal promoters are more conserved than their neighbors. We found that substitutions are predominantly seen in less important sites and that those that occurred tended to have less impact on gene expression than possible alternatives. These results suggest that purifying selection operates on promoter sequences.

Source: Genetics

DOI: 10.1534/genetics.111.133637

Authors: Robert K Arthur, Ilya Ruvinsky

Institution: University of Chicago

Language: English

Topic: Evolution and Genetic Dynamics

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, National Institute of General Medical Sciences

Awards: Genetics and Regulation, G919547230