Year: 2014
Type: article
Abstract: Enzymes underpin physiological function and exhibit dysregulation in many disease-associated microenvironments and aberrant cell processes. Exploiting altered enzyme activity and expression for diagnostics, drug targeting, and drug release is tremendously promising. When combined with booming research in nanobiotechnology, enzyme-responsive nanomaterials used for controlled drug release have achieved significant development and have been studied as an important class of drug delivery strategies in nanomedicine. In this review, we describe enzymes such as proteases, phospholipases and oxidoreductases that serve as delivery triggers. Subsequently, we explore recently developed enzyme-responsive nanomaterials with versatile applications for extracellular and intracellular drug delivery. We conclude by discussing future opportunities and challenges in this area.
Source: Nanoscale
DOI: 10.1039/c4nr04249b
Authors: Quanyin Hu, Prateek S. Katti, Zhen Gu
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Funders: American Diabetes Association, North Carolina State University, Georgia Clinical and Translational Science Alliance, National Institutes of Health, University of North Carolina at Chapel Hill, National Institute of General Medical Sciences, National Center for Advancing Translational Sciences, North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill
OpenAlex ID: W2146536848