N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation
Year: 2000
Type: preprint
Abstract: Members of the myc family of cellular oncogenes have been implicated as transcriptional regulators in pathways that govern cellular proliferation and death. In addition, N-myc and c-myc are essential for completion of murine embryonic development. However, the basis for the evolutionary conservation of myc gene family has remained unclear. To elucidate this issue, we have generated mice in which the endogenous c-myc coding sequences have been replaced with N-myc coding sequences. Strikingly, mice homozygous for this replacement mutation can survive into adulthood and reproduce. Moreover, when expressed from the c-myc locus, N-myc is similarly regulated and functionally complementary to c-myc in the context of various cellular growth and differentiation processes. Therefore, the myc gene family must have evolved, to a large extent, to facilitate differential patterns of expression.
Source: Genes & Development
Authors: Barbara A. Malynn, Ignacio Moreno de Alboran, Rónán C. O'Hagan, Roderick Bronson, Laurie Davidson, Ronald A. DePinho, Frederick W. Alt
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Funders: Howard Hughes Medical Institute, Arthritis Foundation, Jane Coffin Childs Memorial Fund for Medical Research, University of Pennsylvania, National Institutes of Health, National Eye Institute, National Cancer Institute, National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development
OpenAlex ID: W2146613018