Work

Pharmacokinetics of Ofloxacin and Levofloxacin for Prevention and Treatment of Multidrug-Resistant Tuberculosis in Children

Year: 2014

Type: article

Study design: Observational Study

Abstract: Limited data on fluoroquinolone pharmacokinetics and cardiac effects in children exist. Among 22 children receiving drug-resistant tuberculosis prophylaxis or treatment, serum concentrations following oral doses of levofloxacin (15 mg/kg of body weight) and ofloxacin (20 mg/kg) were lower than those expected from existing pediatric data, possibly due to differences in the formulations (crushed tablets). Drug exposures were lower than those in adults following standard doses and below the proposed pharmacodynamic targets, likely due to more rapid elimination in children. No QT prolongation was observed.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02755-13

Authors: S. Thee, A. J. Garcia-Prats, H. M. McIlleron, L. Wiesner, S. Castel, J. Norman, H. R. Draper, P. L. van der Merwe, A. C. Hesseling, H. S. Schaaf

Institutions: Stellenbosch University, Charité – Universitätsmedizin Berlin, University of Cape Town

Language: English

Topic: Antibiotics Pharmacokinetics and Efficacy

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: PHARMACOKINETICS AND TOXICITY OF 2ND LINE ANTI-TB DRUGS IN HIV-INFECTED CHILDREN, Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections, AIDS Clinical Trial Group Laboratory Center, Stellenbosch University Clinical Trials Unit

OpenAlex ID: W2146613560

FWCI: 6.545

Cites: 31

Cited by: 49

Related to: 10