Work

Simplified Synthesis of Isotopically Labeled 5,5-Dimethyl-pyrroline N-Oxide

Year: 2011

Type: article

Abstract: 5,5-Dimethylpyrroline N-oxide (15N) and 5,5-di(trideuteromethyl)pyrroline N-oxide were synthesized from the respective isotopically labeled 2-nitropropane analogs obtained from the reaction of sodium nitrate with 2-halopropanes. This facile, straightforward process allows synthesizing isotopically labeled DMPO analogs in a 4-step reaction without special equipment.

Source: Molecules

DOI: 10.3390/molecules16108428

Authors: Fabian Leinisch, JinJie Jiang, Leesa J. Deterding, Ronald P. Mason

Institutions: National Institutes of Health, National Institute of Environmental Health Sciences

Language: English

Topic: Chemical Reactions and Isotopes

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,258

Funders: National Institutes of Health, National Institute of Environmental Health Sciences