Work

A Neu View of Invasive Lobular Breast Cancer

Year: 2013

Type: article

Abstract: Genome sequencing of relapsed, invasive lobular breast cancer identified actionable mutations in 86% of the cases. HER2 alterations occur in 27% of the cases, including 4 cases with activating HER2 mutations and 1 with a novel HER2-GRB7 gene fusion. This fusion links the HER2 tyrosine kinase domain to the GRB7 src homology 2 (SH2) domain.

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-13-1031

Author: Ron Bose

Institution: Washington University in St. Louis

Language: English

Topic: Breast Lesions and Carcinomas

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute