Year: 2014
Type: article
Abstract: With greater than 500,000 orthopaedic procedures performed in the United States each year requiring a bone graft, the development of novel graft materials is necessary. We report that some porous polymer/ceramic composite scaffolds possess intrinsic osteoinductivity as shown through their capacity to induce in vivo host osteoid mineralization and in vitro stem cell osteogenesis making them attractive synthetic bone graft substitutes. It was discovered that certain low crystallinity ceramics partially dissociate into simple signaling molecules (i.e., calcium and phosphate ions) that induce stem cells to endogenously produce their own osteoinductive proteins. Review of the literature has uncovered a variety of simple signaling molecules (i.e., gases, ions, and redox reagents) capable of inducing other desirable stem cell differentiation through endogenous growth factor production. Inductive simple signaling molecules, which we have termed inducerons, represent a paradigm shift in the field of regenerative engineering where they can be utilized in place of recombinant protein growth factors.
Source: PLoS ONE
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,382
Awards: G3713866268, Polymer/Ceramic Composites for Tissue Engineering, EFRI-CBE: Biological, Chemical, and Mechanical Surface Cues for Cell Migration, Proliferation, and Differentiation: An Integrated Approach to Regeneration of New Tissues, Enhanced Osteoinduction and Angioinduction via Polymer/CaO2 Bone Tissue Engineeri, G9000289708
OpenAlex ID: W2146743949