Work

Manipulation of working memory information is impaired in Parkinson's disease and related to working memory capacity.

Year: 2002

Type: article

Abstract: It has been suggested that in patients with Parkinson's disease (PD), difficulties in the manipulation of information, which result in problems in executive tasks, are related to a reduction of working memory capacity (J. D. E. Gabrieli, J. Singh, G. T. Stebbins, & C. G. Goetz, 1996). The present study selectively varied the manipulation demand irrespective of the maintenance requirement. In a group of 14 PD patients, performance declined overproportionally with the increasing task demand and was significantly correlated with a measure of working memory capacity. These results suggest that the complexity of working memory processing may decisively contribute to the exhaustion of resources in PD patients. Increasing complexity may either affect their manipulation ability directly or impede the management of inhibitory control requirements inherent to the task.

Source: Neuropsychology

DOI: 10.1037//0894-4105.16.4.577

Authors: P. Bublak, U. M�ller, G. Gr�n, M. Reuter, D. Y. von Cramon

Institutions: Max Planck Society, Max Planck Institute for Human Cognitive and Brain Sciences, Catholic University of Eichstätt-Ingolstadt, Leipzig University

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2146748399