Work

Complex Story of the Genetic Origins of Pediatric Heart Disease

Year: 2010

Type: editorial

Abstract: P ediatric heart disease, aka cardiovascular disease in the young, comprises varied phenotypes, including cardiovascular malformations, cardiomyopathies, vasculopathies (eg, Marfan syndrome), and cardiac arrhythmias.Cardiovascular malformations are a major component of pediatric heart disease and constitute a substantial portion of clinically significant birth defects, with a definition-dependent estimated incidence of 4 to 50 per 1000 live births.1,2 Despite advances in diagnosis and therapy, the morbidity and mortality associated with cardiovascular malformations and other forms of pediatric heart disease make them important clinical problems.Thus, there has been considerable interest in understanding their cause.

Source: Circulation

DOI: 10.1161/cir.0b013e3181d98516

Authors: D. Woodrow Benson, Lisa J. Martin

Institutions: Cincinnati Children's Hospital Medical Center, University of Cincinnati

Language: English

Topic: Congenital heart defects research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute