Year: 2009
Type: review
Abstract: Signal transduction along the Ras/MAPK pathway has been generally thought to take place at the plasma membrane. It is now evident that the plasma membrane is not the only platform capable of Ras/MAPK signal induction. Fusion of Ras with green fluorescent protein and the development of genetically encoded fluorescent probes for Ras activation have revealed signaling events on a variety of intracellular membranes including endosomes, the Golgi apparatus and the endoplasmic reticulum. Thus, the Ras/MAPK pathway is spatially compartmentalized within cells and this may afford greater complexity of signal output.
Source: Molecular Oncology
Institutions: NYU Langone Health, New York University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: Compartment Specific Signaling of Ras, Mechanisms of Signal Transduction by Ras Proteins, Regulation of K-Ras by a Farnesyl-electrostatic Switch, Isoprenylcysteine Carboxyl Methyltransferase (ICMT) as a Target in NRAS Driven Melanoma - Resubmission - 1, Medical Scientist Research Service Award, Structure/Function Analysis of Icmt, G6543526009, G6923034717, G6965995057, MECHANISMS OF SIGNAL TRANSDUCTION BY RAS PROTEINS, Mechanisms of Signal Transduction by Ras Proteins, G9000133570, G983208348
OpenAlex ID: W2146889169