Get started
Work

Extrasynaptic Localization of Inactivating Calcium-Activated Potassium Channels in Mouse Inner Hair Cells

Year: 2004
Type: article
Abstract: Auditory hair cells from nonmammalian vertebrates are electrically tuned to specific sound frequencies primarily by the interactions of voltage-gated calcium channels and calcium-activated potassium (BK) channels colocalized at synaptic active zones. Mammalian inner hair cells are not electrically tuned and, yet, BK channels are also thought to reside at active zones. Using patch-clamp recordings and immunofluorescence, we characterized BK channel expression in mouse inner hair cells. Unexpectedly, these channels have inactivating currents and are clustered near the apex of the cell away from synaptic sites near the base. These results indicate a novel function of BK channels in mammalian inner hair cells and provide a framework for future research.
DOI: 10.1523/jneurosci.3162-04.2004
Institutions: Howard Hughes Medical Institute, Stanford Medicine, Stanford University, Johns Hopkins University, Johns Hopkins Medicine, University of California, Davis
Language: English
Subfield: Sensory Systems
Open Access status: hybrid
Funders: National Science Foundation, Howard Hughes Medical Institute, G. Harold and Leila Y. Mathers Foundation, National Institutes of Health, National Institute on Deafness and Other Communication Disorders, National Institute of Neurological Disorders and Stroke
OpenAlex ID: W2146950413
FWCI: 3.564
Cites: 23
Cited by: 90
Related to: 10