Work

Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1

Year: 2004

Type: preprint

Abstract: Aneuploidy, resulting from chromosome missegregation during meiosis, is a major cause of human infertility and birth defects. However, its molecular basis remains incompletely understood. Here we have identified a spectrum of chromosome anomalies in embryos of zebrafish homozygous for a hypomorphic mutation in Mps1, a kinase required for the mitotic checkpoint. These aneuploidies are caused by meiotic error and result in severe developmental defects. Our results reveal Mps1 as a critical regulator of chromosome number in zebrafish, and demonstrate how slight genetic perturbation of a mitotic checkpoint factor can dramatically reduce the fidelity of chromosome segregation during vertebrate meiosis.

Source: Genes & Development

DOI: 10.1101/gad.1182604

Authors: Kenneth D. Poss, Alex Nechiporuk, Keith F. Stringer, Charles Lee, Mark T. Keating