Year: 2014
Type: article
Abstract: Bricklayers may be exposed to several lung carcinogens, including crystalline silica and asbestos. Previous studies that analyzed lung cancer risk among these workers had several study design limitations. We examined lung cancer risk among bricklayers within SYNERGY, a large international pooled analysis of case-control studies on lung cancer and the joint effects of occupational carcinogens. For men ever employed as bricklayers we estimated odds ratios (OR) and 95% confidence intervals (CI) adjusted for study center, age, lifetime smoking history and employment in occupations with exposures to known or suspected lung carcinogens. Among 15,608 cases and 18,531 controls, there were 695 cases and 469 controls who had ever worked as bricklayers (OR: 1.47; 95% CI: 1.28-1.68). In studies using population controls the OR was 1.55 (95% CI: 1.32-1.81, 540/349 cases/controls), while it was 1.24 (95% CI: 0.93-1.64, 155/120 cases/controls) in hospital-based studies. There was a clear positive trend with length of employment (p < 0.001). The relative risk was higher for squamous (OR: 1.68, 95% CI: 1.42-1.98, 309 cases) and small cell carcinomas (OR: 1.78, 95% CI: 1.44-2.20, 140 cases), than for adenocarcinoma (OR: 1.17, 95% CI: 0.95-1.43, 150 cases) (p-homogeneity: 0.0007). ORs were still elevated after additional adjustment for education and in analyses using blue collar workers as referents. This study provided robust evidence of increased lung cancer risk in bricklayers. Although non-causal explanations cannot be completely ruled out, the association is plausible in view of the potential for exposure to several carcinogens, notably crystalline silica and to a lesser extent asbestos.
Source: International Journal of Cancer
DOI: 10.1002/ijc.28986
Authors: Dario Consonni, Sara De Matteis, Angela C. Pesatori, Pier Alberto Bertazzi, Ann C. Olsson, Hans Kromhout, Susan Peters, Roel C.H. Vermeulen, Beate Pesch, Thomas Brüning, Benjamin Kendzia, Thomas Behrens, Isabelle Stücker, Florence Guida, Heinz‐Erich Wichmann, Irene Brüske, Maria Teresa Landi, Neil E. Caporaso, Per Gustavsson, Nils Plato, Lap Ah Tse, Ignatius Tak‐sun Yu, Karl‐Heinz Jöckel, Wolfgang Ahrens, Hermann Pohlabeln, Franco Merletti, Lorenzo Richiardi, Lorenzo Simonato, Francesco Forastiere, Jack Siemiatycki, Marie‐Élise Parent, Adonina Tardón, Paolo Boffetta, David Zaridze, Ying Chen, John K. Field, Andrea 't Mannetje, Neil Pearce, John McLaughlin, Paul Demers, Jolanta Lissowska, Neonila Szeszenia‐Dabrowska, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Peter Rudnai, Eleonóra Fabiánová, Rodica Stanescu Dumitru, H. B(as) Bueno‐de‐Mesquita, Joachim Schüz, Kurt Straif
Institutions: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Imperial College London, Karolinska Institutet, Centre international de recherche sur le cancer, Utrecht University, The University of Western Australia, Institute for Prevention and Occupational Medicine, Ruhr University Bochum, Université Paris-Sud, Inserm, Centre de recherche en Epidémiologie et Santé des Populations, Helmholtz Munich, National Institutes of Health, National Cancer Institute, Chinese University of Hong Kong, Essen University Hospital, University of Duisburg-Essen, University of Bremen, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Piedmont Reference Center for Epidemiology and Cancer Prevention, University of Turin, University of Padua, ASL Roma, Université de Montréal, Institut National de la Recherche Scientifique, Centre Armand-Frappier Santé Biotechnologie, Universidad de Oviedo, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, International Prevention Research Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Russian Cancer Research Center NN Blokhin, University of Liverpool, Arthritis Research UK, Keele University, Massey University, London School of Hygiene & Tropical Medicine, Lunenfeld-Tanenbaum Research Institute, Cancer Care Ontario, Occupational Cancer Research Centre, The Maria Sklodowska-Curie National Research Institute of Oncology, Nofer Institute of Occupational Medicine, Charles University, Masaryk Memorial Cancer Institute, Palacký University Olomouc, Orszagos Kornyezetegeszsegugyi Intezet, Public Health Authority of the Slovak Republic, University Medical Center Utrecht, National Institute for Public Health and the Environment
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,030
Funders: Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Compagnia di San Paolo, Cancer Care Ontario, Workplace Safety and Insurance Board, National Institute for Health and Care Research, European Commission, Cancer Society of New Zealand, Agence Nationale de la Recherche, Fondation pour la Recherche Médicale, Deutsche Gesetzliche Unfallversicherung, Naturvårdsverket, Fondation de France, Chinese University of Hong Kong, Associazione Italiana per la Ricerca sul Cancro, Institut National Du Cancer, Universidad de Oviedo, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro, Lottery Health Research, Institut de Veille Sanitaire, Regione Lazio, Regione Lombardia, Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie, New Zealand Department of Labour, Dirección General de Tráfico, Ministry of Labour and Social Protection of the Russian Federation, National Institutes of Health, Department of Geological Sciences, University of Alabama, Health Research Council of New Zealand, National Cancer Institute
OpenAlex ID: W2147015861