Work

Mechanical evaluation of a tissue-engineered zone of calcification in a bone–hydrogel osteochondral construct

Year: 2013

Type: article

Abstract: The objective of this study was to test the hypothesis that mechanical properties of artificial osteochondral constructs can be improved by a tissue-engineered zone of calcification (teZCC) at the bone-hydrogel interface. Experimental push-off tests were performed on osteochondral constructs with or without a teZCC. In parallel, a numerical model of the osteochondral defect treatment was developed and validated against experimental results. Experimental results showed that the shear strength at the bone-hydrogel interface increased by 100% with the teZCC. Numerical predictions of the osteochondral defect treatment showed that the shear stress at the bone-hydrogel interface was reduced with the teZCC. We conclude that a teZCC in osteochondral constructs can provide two improvements. First, it increases the strength of the bone-hydrogel interface and second, it reduces the stress at this interface.

Source: Computer Methods in Biomechanics & Biomedical Engineering

DOI: 10.1080/10255842.2013.794898

Authors: Jérôme Hollenstein, Alexandre Terrier, Esther Cory, Albert C. Chen, Robert L. Sah, Dominique P. Pioletti

Institutions: University of California San Diego, École Polytechnique Fédérale de Lausanne

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: AO Foundation, National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases