Year: 2014
Type: article
Abstract: A healthy 64-year-old man underwent a prostate biopsy in 1996 that was triggered by a prostate-specific antigen (PSA) measurement of 7.1 ng/mL, and was found on transrectal ultrasound to have a prostate volume of 63 mL and two small foci of Gleason score 5 adenocarcinoma from the left gland (biopsies from the right were negative).Digital rectal examination (DRE) was normal except for prostatic enlargement (stage T1c).The patient chose to enter an active surveillance program as an alternative to curative intervention, and underwent observation with serial PSA measurements and surveillance prostate biopsies (Fig 1A).His first surveillance biopsy performed 1 year after the diagnostic biopsy revealed a prostate volume of 75 mL and one core of Gleason score 6 adenocarcinoma from the same region as the diagnostic biopsy.In 2007, at age 75 years, after a total of 12 surveillance biopsies failed to demonstrate any high-grade components (Gleason grade 4 or 5), serial biopsies were discontinued and he continued to undergo follow-up with DRE and PSA measurements at 6-month intervals (Fig 1A ; PIN, prostatic intraepithelial neoplasia;
Source: Journal of Clinical Oncology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2147170136