Work

Characterization and functions of beta defensins in the epididymis

Year: 2007

Type: review

Abstract: The epididymal beta-defensins have evolved by repeated gene duplication and divergence to encode a family of proteins that provide direct protection against pathogens and also support the male reproductive tract in its primary function. Male tract defensins also facilitate recovery from pathogen attack. The beta-defensins possess ancient conserved sequence and structural features widespread in multi-cellular organisms, suggesting fundamental roles in species survival. Primate SPAG11, the functional fusion of two ancestrally independent beta-defensin genes, produces a large family of alternatively spliced transcripts that are expressed according to tissue-specific and species-specific constraints. The complexity of SPAG11 varies in different branches of mammalian evolution. Interactions of human SPAG11D with host proteins indicate involvement in multiple signaling pathways.

Source: Asian Journal of Andrology

DOI: 10.1111/j.1745-7262.2007.00298.x

Authors: Susan H. Hall, Suresh Yenugu, Yashwanth Radhakrishnan, Maria Christina W. Avellar, Peter Petrusz, Frank S. French

Institutions: University of North Carolina at Chapel Hill, Pondicherry University, Universidade Federal de São Paulo

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $711