Year: 2015
Type: article
Abstract: Grade IV astrocytoma, termed glioblastoma multiforme (GBM) is one the most aggressive malignancies known to man. Despite intensive therapies, the median survival has remained approximately 15months. One of the major challenges to the treatment of CNS malignancies is the blood brain barrier (BBB). The barrier is designed to be incredibly selective, which means few therapeutics given to patients will reliably arrive at the site of the malignancy. To overcome the BBB and low blood flow that tends to occur within these tumors, various biodegradable materials, polymers and nanoparticles that can slowly release therapeutics at the site of the tumor have been developed.
Source: EBioMedicine
Authors: Jason Miska, Maciej S. Lesniak
Institution: University of Chicago
Language: English
Subfield: Genetics (clinical)
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,780
OpenAlex ID: W2147275382