Work

Intranasal Granulocyte-Macrophage Colony-Stimulating Factor Reduces theAspergillusBurden in an Immunosuppressed Murine Model of Pulmonary Aspergillosis

Year: 2007

Type: article

Abstract: We demonstrated that intranasal granulocyte-macrophage colony-stimulating factor given to immunosuppressed mice infected with pulmonary aspergillosis resulted in a sixfold reduction in the lung fungal burden compared to the result for saline-treated mice (P = 0.045). These data suggest that lung-targeted immunotherapy may be complementary to antifungal agents and may improve patient responses.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00760-07

Authors: Gerardo Quezada, Nadezhda V. Koshkina, Patrick Zweidler-McKay, Zichao Zhou, Dimitrios P. Kontoyiannis, Eugenie S. Kleinerman

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Pfizer, Enzon Pharmaceuticals, Astellas Pharma