Work

SMART: identification and annotation of domains from signalling and extracellular protein sequences

Year: 1999

Type: article

Abstract: SMART is a simple modular architecture research tool and database that provides domain identification and annotation on the WWW (http://coot.embl-heidelberg.de/SMART). The tool compares query sequences with its databases of domain sequences and multiple alignments whilst concurrently identifying compositionally biased regions such as signal peptide, transmembrane and coiled coil segments. Annotated and unannotated regions of the sequence can be used as queries in searches of sequence databases. The SMART alignment collection represents more than 250 signalling and extracellular domains. Each alignment is curated to assign appropriate domain boundaries and to ensure its quality. In addition, each domain is annotated extensively with respect to cellular localisation, species distribution, functional class, tertiary structure and functionally important residues.

Source: Nucleic Acids Research

DOI: 10.1093/nar/27.1.229

Authors: C. P. Ponting, J. Schultz, F. Milpetz, P. Bork

Institutions: University of Oxford, European Molecular Biology Laboratory, European Molecular Biology Laboratory

Language: English

Topic: Genomics and Phylogenetic Studies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Wellcome Trust, Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung

OpenAlex ID: W2147285856