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Expression of EMMPRIN Modulates Mediators of Tumor Invasion in Oral Squamous Cell Carcinoma

Year: 2013

Type: article

Abstract: Squamous cell carcinoma (SCC) accounts for 96 percent of all intraoral malignancies. The five-year survival rate is 50 percent and has not improved in 60 years. During SCC progression, subsets of SCC cells undergo an epithelial-to-mesenchymal transition (EMT) to become highly invasive. The extracellular matrix metalloproteinase inducer (EMMPRIN) contributes to EMT by activating local matrix metalloproteinases (MMPs). In this study, we found that EMMPRIN modulates the invasive phenotype and may be a potential therapeutic target.

Source: Journal of the California Dental Association

DOI: 10.1080/19424396.2013.12222372

Authors: Amanda Siu, Joy Chang, Casey Lee, Stacey Lee, Carlin LEE, Daniel M. Ramos

Institutions: University of California, San Francisco, University of California, Davis

Language: English

Topic: Protease and Inhibitor Mechanisms

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W21472879

FWCI: 0.703

Cites: 18

Cited by: 9

Related to: 10