Year: 2013
Type: article
Abstract: Compared with single-focus optical-resolution photoacoustic microscopy (OR-PAM), multifocal OR-PAM utilizes both multifocal optical illumination and an ultrasonic array transducer, significantly increasing the imaging speed. A reflection-mode multifocal OR-PAM system based on a microlens array that provides multiple foci as well as an ultrasonic array transducer that receives the excited photoacoustic waves from all foci simultaneously is presented. Using a customized microprism to reflect the incident laser beam to the microlens array, the multiple optical foci are aligned confocally with the focal zone of the ultrasonic array transducer. Experiments show the reflection-mode multifocal OR-PAM is capable of imaging microvessels in vivo, and it can image a 6×5×2.5 mm³ volume at 16 μm lateral resolution in ∼2.5 min, which was limited by the signal multiplexing ratio and laser pulse repetition rate.
Source: Journal of Biomedical Optics
Authors: Guo Li, Konstantin I. Maslov, Lihong V. Wang
Institution: Washington University in St. Louis
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
Awards: Photon tunneling: Shedding new light on biomedicine, G1952371934, RECOVERY OF OPTICAL ABSORPTION COEFFICIENT IN QUANTITATIVE PHOTOACOUSTIC IMAGING, Confocal Photacoustic Microscopy: Technology Development, Photoacoustic endoscopy of Barretts esophagus, Photoacoustic / Optical / Ultrasonic Imaging of Sentinel Lymph Nodes and Metastas, Monitoring of Breast Neoadjuvant Therapy by Thermo- and Photo- Acoustic Tomograph, PHOTOACOUSTIC MICROSCOPY OF NEOVASCULARIZATION IN RENAL CANCER GROWTH AND THERAPY, G9000084353
OpenAlex ID: W2147342803