Year: 2008
Type: review
Abstract: The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.
Source: Retrovirology
Authors: Mathieu Boxus, Jean-Claude Twizere, Sébastien Legros, Jean-François Dewulf, Richard Kettmann, Luc Willems
Institution: Gembloux Agro-Bio Tech
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,890
Award: G7404019914
OpenAlex ID: W2147372038