Work

Characterization of Complementary DNA Encoding the Precursor for Gonadotropin-Releasing Hormone and Its Associated Peptide from a Teleost Fish

Year: 1991

Type: article

Abstract: Reproductive maturity among male African cichlids Haplochromis burtoni is cued by a series of environmental and social interactions and is mediated physiologically by GnRH. A cDNA clone encoding the precursor for GnRH was isolated from this teleost. The molecular architecture of the predicted prohormone is analogous to that of the previously characterized mammalian forms; however, the predicted sequence of the associated peptide is strikingly different. Attempts to isolate a putative second precursor using low stringency hybridization were not successful despite evidence that a second related decapeptide exists in at least some teleost species.

Source: Molecular Endocrinology

DOI: 10.1210/mend-5-7-931

Authors: Chris T. Bond, Richard C. Francis, Russell D. Fernald, John P. Adelman

Institutions: Oregon Health & Science University, Vollum Institute, Stanford University

Language: English

Topic: Hypothalamic control of reproductive hormones

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1294097127, CHARACTERIZATION AND FUNCTION OF THE GNRH:SH GENE LOCUS, G5308762349, SOCIAL AND PHYSIOLOGICAL REGULATION OF MATURATION