Work

Mitochondria are selective targets for the protective effects of heat shock against oxidative injury.

Year: 1996

Type: article

Abstract: Heat shock (HS) proteins (HSPs) induce protection against a number of stresses distinct from HS, including reactive oxygen species. In the human premonocytic line U937, we investigated in whole cells the effects of preexposure to HS and exposure to hydrogen peroxide (H2O2) on mitochondrial membrane potential, mass, and ultrastructure. HS prevented H2O2-induced alterations in mitochondrial membrane potential and cristae formation while increasing expression of HSPs and the protein product of bcl-2. Protection correlated best with the expression of the 70-kDa HSP, hsp70. We propose that mitochondria represent a selective target for HS-mediated protection against oxidative injury.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.93.13.6458

Authors: B S Polla, S Kantengwa, D François, S Salvioli, C Franceschi, C Marsac, A Cossarizza

Institutions: University of Geneva, Inserm, University of Modena and Reggio Emilia, Istituto delle Scienze Neurologiche di Bologna

Language: English

Topic: Heat shock proteins research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2147464247

FWCI: 8.547

Cites: 47

Cited by: 400

Related to: 10