Electro-spinning of poly (ethylene-co-vinyl alcohol) (EVOH) nanofibres for medical applications and its mechanical properties
Year: 2012
Type: dissertation
Abstract: Skin wound healing is an urgent problem in clinical treatment, in particular, with a military context.Although significant advances have been made in treating skin wounds, traditional methods face several challenges, e.g., limited donor skin tissue for transplants and inflammation over the period of long term healing.To address these challenges, in this study we present a method to fabricate Poly (ethylene-co-vinyl alcohol) (EVOH) nanofibres encapsulated with the Ag nanoparticle, using the electro-spinning technique.The manufacturing process of nanofibres by electro-spinning is the subject of the present research.Electro-spinning is a process which produces nanofibres through the electrically charged jet of a polymer solution.While the principle has long been understood, the process of forming them still remains difficult to control.In its simplest form, the technique consists of a pipette to hold the polymer solution, two electrodes and a DC voltage supply over a 10 KV range.The polymer dropping from the tip of the pipette is drawn into a jet which is electrically charged and spun into fine fibres by the electronic field.An appropriate combination of the control parameters, such as the charge voltage, density and viscosity of the polymer solution and the travel distance of the jet, etc. will lead to the production of fibres with diameters in the range of 10 -7~8 meters.The fibres can then be collected on the surface of a grounded target.The fibres in this study were fabricated with controlled diameters (50 nm -3 µm) by regulating three main parameters, namely, a concentrated EVOH solution, the electric voltage and the distance between the injection needle tip (high voltage point) and the fibre collector.Ag was added to the nanofibres to offer long term anti-inflammation properties by the slow release of Ag nanoparticles through the gradual degradation of the EVOH nanofibre.The method developed here could lead to new dressing materials for the treatment of skin wounds.The thin EVOH nanofibre sheets obtained from electro-spinning were tested in uniaxial tension for their mechanical properties, with a view to the possibilities of V Table of contents Acknowledgements…………………………………………………………..……....
Author: Chao Xu
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2147472232