Work

Structural basis for Na + -sensitivity in dopamine D2 and D3 receptors

Year: 2015

Type: article

Abstract: To understand the structural basis for the Na(+)-sensitivity of ligand binding to dopamine D2-like receptors, using computational analysis in combination with binding assays, we identified interactions critical in propagating the impact of Na(+) on receptor conformations and on the ligand-binding site. Our findings expand the pharmacologically-relevant conformational spectrum of these receptors.

Source: Chemical Communications

DOI: 10.1039/c5cc02204e

Authors: Mayako Michino, R. Benjamin Free, Trevor B. Doyle, David R. Sibley, Lei Shi

Institutions: Cornell University, Weill Cornell Medicine, National Institutes of Health, National Institute of Neurological Disorders and Stroke

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institutes of Health

Award: G9000198032