Work

Heterogeneity of DNA deletion in gamma delta beta-thalassemia.

Year: 1981

Type: article

Abstract: By restriction endonuclease mapping, gene cloning, and DNA sequencing we have determined the region of DNA that is deleted in a family with gamma delta beta-thalassemia. The deletion removes the linked epsilon, gamma-, and delta-globin structural genes and terminates within the coding portion of the beta-globin gene. Since the extent of DNA deletion in this family differs from that reported in another family, we conclude that gamma delta beta-thalassemia is heterogeneous at the molecular level.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci110105

Authors: S H Orkin, S C Goff, D G Nathan

Institution: Harvard University

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: March of Dimes Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute