Work

Structural genomics: Computational methods for structure analysis

Year: 2003

Type: review

Abstract: The success of structural genomics initiatives requires the development and application of tools for structure analysis, prediction, and annotation. In this paper we review recent developments in these areas; specifically structure alignment, the detection of remote homologs and analogs, homology modeling and the use of structures to predict function. We also discuss various rationales for structural genomics initiatives. These include the structure-based clustering of sequence space and genome-wide function assignment. It is also argued that structural genomics can be integrated into more traditional biological research if specific biological questions are included in target selection strategies.

Source: Protein Science

DOI: 10.1110/ps.0242903

Authors: Sharon Goldsmith‐Fischman, Barry Honig

Institutions: Howard Hughes Medical Institute, Columbia University

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Science Foundation, National Institutes of Health, National Institute of General Medical Sciences, Division of Biological Infrastructure