Transgenic copper/zinc superoxide dismutase modulates susceptibility to type I diabetes.
Year: 1994
Type: article
Abstract: A growing body of evidence suggests that active oxygen is an important participant in the destruction of the pancreatic beta cell, which, in turn, leads to type I or insulin-dependent diabetes mellitus. Consequently, genetic factors predisposing susceptibility to insulin-dependent diabetes mellitus may include those that determine active oxygen metabolism. A direct test of this hypothesis is provided by a transgenic model for increased activity of Cu/Zn superoxide dismutase (EC 1.15.1.1), a principal radical scavenging enzyme. Here we demonstrate that elevated levels of this enzyme provided by a Cu/Zn superoxide dismutase transgene enhance the tolerance of pancreatic beta cells to oxidative stress-induced diabetogenesis. These results show that this transgenic approach holds promise for revealing the role of reactive oxygen in autoimmune models of diabetogenesis as well as in other models of disease pathology in which active oxygen has been implicated.
Authors: H M Kubisch, J Wang, R Luche, E Carlson, T M Bray, C J Epstein, J P Phillips
Institutions: University of California, San Francisco, University of Guelph
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Awards: G595133384, BIOLOGY OF DOWN SYNDROME
OpenAlex ID: W2147577157