Work

Memory CD4 + T Lymphocytes in the Gastrointestinal Tract Are a Major Source of Cell-Associated Simian Immunodeficiency Virus in Chronic Nonpathogenic Infection of African Green Monkeys

Year: 2012

Type: article

Abstract: Simian immunodeficiency virus (SIV) infection of natural hosts is characterized by nonpathogenic chronic viremia, maintenance of gastrointestinal epithelial barrier integrity, and low numbers of target cells. Assessment of cell-associated virus load in T cell subsets in multiple anatomic compartments of chronically SIV-infected sabeus African green monkeys (AGMs) revealed that gastrointestinal memory CD4(+) T lymphocytes are a major source of cell-associated virus and a significant contributor to SIV viremia in AGMs.

Source: Journal of Virology

DOI: 10.1128/jvi.01556-12

Authors: Joern E. Schmitz, Zhong-Min Ma, Emily A. Hagan, Andrew B. Wilks, Kathryn L. Furr, Caitlyn H. Linde, Roland C. Zahn, Jason M. Brenchley, Christopher J. Miller, Sallie R. Permar

Institutions: Beth Israel Deaconess Medical Center, University of California, Davis, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Duke Medical Center

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: (CHAVI) Center for HIV/AIDS Vaccine Immunology, G2026096560, G2149684344, SIV-specific Immunity in breast milk during infection and after vaccination, G5566925475, Immune control of SIVagm replication in vivo, (CHAVI) Center for HIV/AIDS Vaccine Immunology, G965293143

OpenAlex ID: W2148000177

FWCI: 0.658

Cites: 29

Cited by: 11

Related to: 10