Work

Chemistry and biology of resorcylic acid lactones

Year: 2006

Type: review

Abstract: While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor while other members such as hypothemycin, LL-Z1640-2 and LL-783,277 are potent kinase inhibitors have stimulated a renewed interest in this family of natural products. The recent developments regarding the chemistry and biology of RALs are reviewed.

Source: Chemical Communications

DOI: 10.1039/b610344h

Authors: Nicolas Winssinger, Sofia Barluenga

Institution: Institut de Science et d'Ingénierie Supramoléculaires

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2148013004

FWCI: 0.863

Cites: 58

Cited by: 256

Related to: 9