Work

Risk Factors for Graft Failure and Survival after Reduced Intensity (RIC) Conditioning Allogeneic Hematopoietic Cell Transplantation (HCT) for Myelofibrosis

Year: 2014

Type: article

Abstract: Reduced intensity conditioning (RIC) HSCT is a potentially curative therapy for Myelofibrosis (MF), but graft failure is a major cause of treatment failure. We evaluated the outcomes and risk factors for graft failure and survival in patients undergoing RIC HSCT. We performed a retrospective review of all patients receiving a first RIC HSCT for MF at Dana Farber Cancer Institute/Brigham and Women's Hospital between January 1, 2000 and December 31, 2012. Primary graft failure (PGF) was defined as the inability to achieve an ANC greater than 0.5x109/L for three consecutive days.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2013.12.021