Work

Solution‐Phase Mixture Synthesis with Double‐Separation Tagging: Double Demixing of a Single Mixture Provides a Stereoisomer Library of 16 Individual Murisolins

Year: 2005

Type: article

Abstract: Two tags are better than one: Sixteen individual stereoisomers of murisolin (see scheme) are synthesized together and isolated in pure form with the aid of a double-separation tagging procedure. A strategy for solution-phase stereoisomer synthesis based on double-separation tagging and double demixing is implemented with fluoroalkyl and oligoethylene glycol (OEG, (OCH2CH2)nOCH3) tags.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200501989

Authors: Craig S. Wilcox, Venugopal Gudipati, Hejun Lu, Serhan Turkyilmaz, Dennis P. Curran

Institution: University of Pittsburgh

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2148226737

FWCI: 1.632

Cites: 17

Cited by: 29

Related to: 10