Work

Triacylglycerol Metabolism In Adipose Tissue

Year: 2007

Type: article

Abstract: Triacylglycerol (TAG) in adipose tissue serves as the major energy storage form in higher eukaryotes. Obesity, resulting from excess white adipose tissue, has increased dramatically in recent years resulting in a serious public health problem. Understanding of adipocyte-specific TAG synthesis and hydrolysis is critical to the development of strategies to treat and prevent obesity and its closely associated diseases, for example, Type 2 diabetes, hypertension and atherosclerosis. In this review, we present an overview of the major enzymes in TAG synthesis and lipolysis, including the recent discovery of a novel adipocyte TAG hydrolase.

Source: Future Lipidology

DOI: 10.2217/17460875.2.2.229

Authors: Maryam Ahmadian, Robin E Duncan, Kathy Jaworski, Eszter Sarkadi-Nagy, Hei Sook Sul

Institution: University of California, Berkeley

Language: English

Topic: Lipid metabolism and biosynthesis

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Diabetes and Digestive and Kidney Diseases