Work

The T‐cell‐specific adapter protein family: TSAd, ALX, and SH2D4A/SH2D4B

Year: 2009

Type: review

Abstract: Adapter proteins play key roles in intracellular signal transduction through complex formation with catalytically active signaling molecules. In T lymphocytes, the role of several different types of adapter proteins in T-cell antigen receptor signal transduction is well established. An exception to this is the family of T-cell-specific adapter (TSAd) proteins comprising of TSAd, adapter protein of unknown function (ALX), SH2D4A, and SH2D4B. Only recently has the function of these adapters in T-cell signal transduction been explored. Here, we discuss advances in our understanding of the role of this family of adapter proteins in T cells. Their function as regulators of signal transduction in other cell types is also discussed.

Source: Immunological Reviews

DOI: 10.1111/j.1600-065x.2009.00829.x

Authors: Philip E. Lapinski, Jennifer A. Oliver, Jennifer N. Bodie, Francesc Marti, Philip D. King

Institutions: University of Michigan, Michigan Medicine

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

Funders: American Heart Association, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Award: Control of T cell activation by the TSAd adapter protein