Work

Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1

Year: 2008

Type: article

Study design: Case Report

Abstract: We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.

Source: New England Journal of Medicine

DOI: 10.1056/nejmoa0800251

Authors: Naomi N. Hunder, Herschel Wallen, Jianhong Cao, Deborah W. Hendricks, John Z. Reilly, Rebecca Rodmyre, Achim Jungbluth, Sacha Gnjatic, John A. Thompson, Cassian Yee

Institutions: Fred Hutch Cancer Center, Memorial Sloan Kettering Cancer Center, University of Washington

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Cancer Institute, National Center for Research Resources

Awards: G1390133456, Potentiating Adoptive T Cell Therapy by Immunomodulation, G2623056496, G4203427171, G8564951585

OpenAlex ID: W2148360952

FWCI: 28.8

Cites: 21

Cited by: 912

Related to: 10