Year: 2013
Type: dissertation
Abstract: Background: Carotid intima-media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predict future cardiovascular disease events.Methods: We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.We then sought additional evidence to support our fi ndings among 11,273 individuals using data from 7 additional studies.Results: In the combined meta-analysis, we identifi ed three genomic regions associated with common cIMT and two different regions associated with the presence of carotid plaque (P<5×10 -8 ).The associated SNPs mapped in, or near, genes related to cellular-signaling, lipid metabolism, and blood pressure homeostasis and two of the regions were associated with coronary artery disease (P<0.006) in the CARDIoGRAM Consortium.Conclusions: Our fi ndings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events.
Author: Maryam Kavousi
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2148375687