Work

Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration

Year: 2010

Type: review

Abstract: Directed cell migration is a physical process that requires dramatic changes in cell shape and adhesion to the extracellular matrix. For efficient movement, these processes must be spatiotemporally coordinated. To a large degree, the morphological changes and physical forces that occur during migration are generated by a dynamic filamentous actin (F-actin) cytoskeleton. Adhesion is regulated by dynamic assemblies of structural and signaling proteins that couple the F-actin cytoskeleton to the extracellular matrix. Here, we review current knowledge of the dynamic organization of the F-actin cytoskeleton in cell migration and the regulation of focal adhesion assembly and disassembly with an emphasis on how mechanical and biochemical signaling between these two systems regulate the coordination of physical processes in cell migration.

Source: Annual Review of Cell and Developmental Biology

DOI: 10.1146/annurev.cellbio.011209.122036

Authors: Margaret L. Gardel, Ian C. Schneider, Yvonne Aratyn-Schaus,, Clare M. Waterman

Institutions: University of Chicago, Iowa State University, National Institutes of Health, National Heart, Lung, and Blood Institute

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Center for Chronic Disease Prevention and Health Promotion

Awards: 2007 NIH Director's Pioneer Award Program (DP1), G4350881250