Year: 2001
Type: article
Abstract: Replicative senescence is the terminal non-proliferative state acquired by normal cells in culture after a finite and constant number of divisions.Initially documented in cultures of human fibroblasts, this phenomenon of limited proliferative capacity has been extended to many cell types and has become a model for aging at the cellular level.Cumulative telomere shortening during cell division has been proposed to be responsible for the induction of cell cycle arrest (1).However, the nature of this anti-proliferative signal and the activation mechanism for the cascades of events ultimately leading to cellular senescence remain unknown.
Source: The Scientific World JOURNAL
DOI: 10.1100/tsw.2001.232
Authors: Juan I. Young, James R. Smith
Institution: Baylor College of Medicine
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $860
OpenAlex ID: W2148573663