CD8 + T Cell Recognition of Cryptic Epitopes Is a Ubiquitous Feature of AIDS Virus Infection
Year: 2010
Type: article
Abstract: Vaccines designed to elicit AIDS virus-specific CD8+ T cells should engender broad responses. Emerging data indicate that alternate reading frames (ARFs) of both human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) encode CD8+ T cell epitopes, termed cryptic epitopes. Here, we show that SIV-specific CD8+ T cells from SIV-infected rhesus macaques target 14 epitopes in eight ARFs during SIV infection. Animals recognized up to five epitopes, totaling nearly one-quarter of the anti-SIV responses. The epitopes were targeted by high-frequency responses as early as 2 weeks postinfection and in the chronic phase. Hence, previously overlooked ARF-encoded epitopes could be important components of AIDS vaccines.
Source: Journal of Virology
DOI: 10.1128/jvi.01419-10
Institution: University of Wisconsin–Madison
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: G1226645368, EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION, G286789154, MHC Typing of Macaques Used in AIDS Research, G3788890150, G3934557094, G422425422, G4561200633, G4688819643, EXTRAMURAL REGIONAL FACILITIES CONSTRUCTION, MHC-bound, SIV-derived, CTL and HTL Epitopes, G832415928, Wisconsin National Primate Research Center Support
OpenAlex ID: W2148581367