Work

Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation

Year: 2011

Type: preprint

Abstract: Long noncoding RNAs (lncRNAs) are differentially expressed under both normal and pathological conditions, implying that they may play important biological functions. Here we examined the expression of lncRNAs during erythropoiesis and identified an erythroid-specific lncRNA with anti-apoptotic activity. Inhibition of this lncRNA blocks erythroid differentiation and promotes apoptosis. Conversely, ectopic expression of this lncRNA can inhibit apoptosis in mouse erythroid cells. This lncRNA represses expression of Pycard, a proapoptotic gene, explaining in part the inhibition of programmed cell death. These findings reveal a novel layer of regulation of cell differentiation and apoptosis by a lncRNA.

Source: Genes & Development

DOI: 10.1101/gad.178780.111

Authors: Wenqian Hu, Bingbing Yuan, Johan Flygare, Harvey F. Lodish

Institutions: Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Life Sciences Research Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases