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75 Loss of PTEN leads to acquired resistance to the PI3Ka inhibitor BYL719: a case of convergent evolution under selective therapeutic pressure

Year: 2014

Type: article

Source: European Journal of Cancer

DOI: 10.1016/s0959-8049(14)70201-1

Authors: P. Castel, D. Juric, M. Griffith, O.L. Griffith, H.H. Won, B. Ainscough, H. Ellis, S. Ebbesen, I. Gopakumar, C. Quadt, M. Peters, D. Solit, S.W. Lowe, E.R. Mardis, M.F. Berger, M. Scaltriti, J. Baselga

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

OpenAlex ID: W2148780533

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