Work

Case-Control Study Comparing De Novo and Daptomycin-Exposed Daptomycin-Nonsusceptible Enterococcus Infections

Year: 2012

Type: article

Abstract: Understanding factors associated with de novo daptomycin-nonsusceptible Enterococcus (DNSE) infections will aid in better understanding the mechanisms of daptomycin nonsusceptibility. We conducted a case-control study to compare patients with DNSE infections who were daptomycin treatment naïve (n = 9) and those with DNSE infections who had exposure to daptomycin (n = 13). Less frequent exposure to antimicrobials, increased susceptibility to nitrofurantoin and gentamicin, and shorter duration of hospitalization were associated with de novo DNSE infection, suggesting a potential community reservoir.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.05918-11

Authors: Theodoros Kelesidis, Angela L. P. Chow, Romney Humphries, Daniel Z. Uslan, David Pegues

Institutions: University of California, Los Angeles, Tan Tock Seng Hospital

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Center for Advancing Translational Sciences