Work

APOE-4 Genotype and Neurophysiological Vulnerability to Alzheimer's and Cognitive Aging

Year: 2009

Type: review

Abstract: Many years before receiving a clinical diagnosis of Alzheimer's disease (AD), patients experience evidence of cognitive decline. Recent studies using a variety of brain imaging technologies have detected subtle changes in brain structure and function in normal adults with a genetic risk for AD; these brain changes have similar pathological features as AD, and some appear to be predictive of future cognitive decline. This review examines the most recent data on brain changes in genetic risk for AD and discusses the benefits and potential risks of detecting individuals at risk.

Source: Annual Review of Clinical Psychology

DOI: 10.1146/annurev.clinpsy.032408.153625

Authors: Susan Bookheimer, Alison Burggren

Institution: University of California, Los Angeles

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Aging